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PulseNet China, a model for future laboratory-based bacterial infectious disease surveillance in China

Wei Li, Shan Lu, Zhigang Cui, Jinghua Cui, Haijian Zhou, Yiqing Wang, Zhujun Shao, Changyun Ye, Biao Kan, Jianguo Xu

Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 366-375 doi: 10.1007/s11684-012-0214-6

Abstract:

Surveillance is critical for the prevention and control of infectious disease.China’s real-time web-based infectious disease reporting system is a distinguished achievement.demand for timely outbreak detection and identification of emerging infectious disease.PulseNet International family; and has been adapting the idea and methodology of PulseNet to develop a modelWe summarized the development progress for the PulseNet China system and discussed it as a model for

Keywords： infectious disease laboratory-based infectious disease surveillance pulse field gel electrophoresis multilocus

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Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1684-2

Abstract:

● This study explored the long-term association by double robust additive models.

Keywords： Air pollution Cerebrovascular disease Incidence Long-term exposure Doubly robust additive model

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A study on specialist or special disease clinics based on big data

Zhuyuan Fang,Xiaowei Fan,Gong Chen

Frontiers of Medicine 2014, Volume 8, Issue 3, Pages 376-381 doi: 10.1007/s11684-014-0356-9

Abstract: implemented through big data technology to find the relevance of different factors in the life cycle of a diseasepaper explores the concept of constructing a big medical data platform and introduces the clinical modelThrough analysis technology, such as artificial neural network and grey model, a medical model can befor specialist and special disease clinics.It establishes a new model for common clinical research for specialist and special disease clinics.

Keywords： big data correlation analysis medical information integration data analysis clinical model

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft hostdisease

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: However, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine model

Keywords： graft vs host disease proteinase-activated receptor murine model hematopoietic stem cell transplantation

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Base editors: development and applications in biomedicine

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 359-387 doi: 10.1007/s11684-023-1013-y

Abstract: biomedicine, including gene function investigation, directed protein evolution, genetic lineage tracing, disease

Keywords： base editing CBE ABE ADAR DdCBE disease model therapeutic application

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et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 354-359 doi: 10.1007/s11684-012-0234-2

Abstract: et’s disease is defined as a multisystemic inflammatory disease.et’s disease. To explore the genetic factors for Beh?et’s disease, our group investigated the association of Beh?et’s disease with multiple immune response genes and has identified multiple Beh?et’s disease-related immunoregulatory pathways in the Chinese Han population.

Keywords： et’s disease SNPs immune gene genetic study

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract:

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality

Keywords： chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction

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Acupuncture for the management of dry eye disease

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 975-983 doi: 10.1007/s11684-022-0923-4

Abstract: The effectiveness of using acupuncture for dry eye disease (DED) is controversial.outcomes of interests were (1) to evaluate the efficacy of acupuncture in improving the ocular surface disease

Keywords： dry eye disease xerophthalmus acupuncture

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Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

Frontiers of Engineering Management 2015, Volume 2, Issue 1, Pages 2-12 doi: 10.15302/J-FEM-2015002

Abstract: the status of major chronic diseases in China, analyzing the key issues and key factors in chronic diseasethe previous projects, this paper proposes the following recommendations as strategies for chronic diseaseWork norms and requirements will then improve the performance and efficiency in chronic disease prevention

Keywords： chronic disease prevention and control strategy and system construction

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Astrocytes in depression and Alzheimer’s disease

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 829-841 doi: 10.1007/s11684-021-0875-0

Abstract: brain diseases may cause psychosocial and cognitive impairment, such as depression and Alzheimer’s diseasedepression and AD has shown that depression might be a prodrome of progressive degenerative neurological disease

Keywords： astrocytes depression Alzheimer’s disease roles mechanisms

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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 649-674 doi: 10.1007/s11684-023-1018-6

Abstract: Minimal residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients

Keywords： MRD solid tumor CTC ctDNA

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Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Frontiers of Medicine 2011, Volume 5, Issue 3, Pages 254-270 doi: 10.1007/s11684-011-0153-7

Abstract: computed tomography (CT) has been widely used in clinical practice for the diagnosis of cardiovascular diseaseangiography has been recognized as the method of choice for detecting and diagnosing head and neck vascular diseaseIn patients with suspected coronary artery disease, although invasive coronary angiography still remainsThe imaging diagnosis of cardiovascular disease is based on a combination of two-dimensional (2D) andan overview of the diagnostic performance of various 2D and 3D CT visualizations in cardiovascular disease

Keywords： cardiovascular disease multislice computed tomography three-dimensional reconstruction diagnosis visualization

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 173-206 doi: 10.1007/s11684-023-0992-z

Abstract: ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease, we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human diseaseWe also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease

Keywords： ferroptosis human disease iron metabolism lipid peroxidation antioxidation

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The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 1-7 doi: 10.1007/s11684-019-0733-5

Abstract: With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children<2 years and elderly≥65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.

Keywords： molecular epidemiology norovirus disease burden genotype China

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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2, Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoVAs disease progressed, a series of complications tend to develop, especially in critically ill patients

Keywords： coronavirus disease 2019 epidemiology pathology radiology clinical characteristics treatment